Isaakios I crossed the Sea of Marmara and took up residence around Honoratos, hunting and exercising for a whole long day, but then returned to Constantinople ill with pleurisy. Treatment is said to have included advice to have sex with a woman, and a burning treatment which might make him infertile. He summoned his brother Ioannes Komnenos who declined his offer of the imperial throne, despite the vain pleas of Ioannes' wife Anna Dalassene to accept it, for the sake of both their family and the empire