Eirene followed her husband as he set out the second time for Kastamon, but fell ill and died in Bithynia, leaving the Pantokrator complex unfinished. Theodoros Prodromos wrote an epitaph, in which she speaks of her descent from Western emperors, her marriage to Ioannes II and his achievements, their eight children, and her becoming a nun before her death. Ioannes and her family took her back to Constantinople, buried and mourned her appropriately, then returned to the army