Nikephoritzes served in the administration of Konstantinos X Doukas but was dismissed when he proved to be so malicious, slanderous and expert in evil deeds as to accuse the empress Eudokia to the emperor of adultery, out of hatred for Michael of Nikomedeia, the logothetes of the dromos. He was dismissed from the central administration as a result of this conduct, and appointed doux of Antioch, but there too he caused trouble by erecting forts and providing excuses for war, provoking the Saracens to retaliate and attack the borders. Unable to fight the Saracens he roused them to fight the Romans, and did not leave in peace even the Antiochenes, confiscating their properties or imposing unreasonable demands, until he was dismissed there too